Infectious Salmon Anaemia was reported in New Brunswick in September 1997. The virus was isolated from several sites by culture on SHK-1 cells and confirmed by monoclonal indirect fluorescent antibody technique. Gross examination revealed branchial pallor, exophthalmos, external ventral petechial haemorrhage, ascites and congested pyloric caecae, lower intestines and spleens. Microscopic examination was characterised by renal interstitial haemorrhage and tubular necrosis, branchial lamellar and filamental congestion and congestion of the intestine and pyloric caecae. Perivascular inflammation was a common finding in the livers examined. The lesions in the kidney were consistent with Haemorrhagic Kidney Syndrome and have been reproduced experimentally. This is the first case report of infectious salmon anaemia in New Brunswick.