Publication Abstract

The registration of chemicals for use in offshore oil and gas extraction processes in the North Sea requires data on the bioaccumulation, toxicity and biodegradability on the individual substances involved. Data relating to these parameters can be determined experimentally by performing the relevant studies or with the use of Quantity Structure Activity Relationships (QSARs). To be acceptable for registration of offshore chemicals, all QSAR calculations must be fully validated. We present a discussion of the use of QSAR data used in Offshore Chemical Notification Scheme (OCNS) registration and review the procedures associated with their validation, including an overview of the relevant scientific principles and what Cefas considers to be an acceptable level of validation.